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Morphology of subcortical brain nuclei is associated with autonomic function in healthy humans.


ABSTRACT: The autonomic nervous system (ANS) is a brain body interface which serves to maintain homeostasis by influencing a plethora of physiological processes, including metabolism, cardiorespiratory regulation and nociception. Accumulating evidence suggests that ANS function is disturbed in numerous prevalent clinical disorders, including irritable bowel syndrome and fibromyalgia. While the brain is a central hub for regulating autonomic function, the association between resting autonomic activity and subcortical morphology has not been comprehensively studied and thus was our aim. In 27 healthy subjects [14 male and 13 female; mean age 30 years (range 22-53 years)], we quantified resting ANS function using validated indices of cardiac sympathetic index (CSI) and parasympathetic cardiac vagal tone (CVT). High resolution structural magnetic resonance imaging scans were acquired, and differences in subcortical nuclei shape, that is, 'deformation', contingent on resting ANS activity were investigated. CSI positively correlated with outward deformation of the brainstem, right nucleus accumbens, right amygdala and bilateral pallidum (all thresholded to corrected P?

SUBMITTER: Ruffle JK 

PROVIDER: S-EPMC6866383 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Morphology of subcortical brain nuclei is associated with autonomic function in healthy humans.

Ruffle James K JK   Coen Steven J SJ   Giampietro Vincent V   Williams Steven C R SCR   Apkarian A Vania AV   Farmer Adam D AD   Aziz Qasim Q  

Human brain mapping 20171028 1


The autonomic nervous system (ANS) is a brain body interface which serves to maintain homeostasis by influencing a plethora of physiological processes, including metabolism, cardiorespiratory regulation and nociception. Accumulating evidence suggests that ANS function is disturbed in numerous prevalent clinical disorders, including irritable bowel syndrome and fibromyalgia. While the brain is a central hub for regulating autonomic function, the association between resting autonomic activity and  ...[more]

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