Dataset Information

Structure tensor informed fibre tractography at 3T.

ABSTRACT: Structure tensor informed fibre tractography (STIFT) based on informing tractography for diffusion-weighted images at 3T and by utilising the structure tensor obtained from gradient-recalled echo (GRE) images at 7T is able to delineate fibres when seed voxels are placed close to the fibre boundaries. However, incorporating data from two different field strengths limits the applicability of STIFT. In this study, STIFT was implemented with both diffusion-weighted images and GRE images acquired at 3T. Instead of using the magnitude GRE data directly for STIFT as in the previous work, the utility of T2 * maps and quantitative susceptibility maps derived from complex-valued GRE data to improve fibre delineation was explored. Single-seed tractography was performed and the results show that the optic radiation reconstructed with STIFT is more distinguishable from the inferior longitudinal fasciculus/inferior fronto-occipital fasciculus complex when compared to standard diffusion-weighted imaging tractography. We further investigated the quantitative effects of STIFT in a group of five healthy volunteers and evaluated its impact on measures of structural connectivity. The framework was extended to evaluate implementations of STIFT based on T2 *-weighted and quantitative susceptibility-weighted images in a whole-brain connectivity study. In terms of connectivity, no systematic differences were found between STIFT and diffusion-weighted imaging tractography, suggesting that local improvements in tractography are not translated to the atlas-based structural connectivity analysis. Nevertheless, the reduction in the number of statistically significant connections in the STIFT connectivity matrix suggests that STIFT can potentially reduce the false-positive connections in fibre tractography.

SUBMITTER: Chan KS

PROVIDER: S-EPMC6866445 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Structure tensor informed fibre tractography at 3T.

Chan Kwok-Shing KS Norris David G DG Marques José P JP

Human brain mapping 20180721 11

Structure tensor informed fibre tractography (STIFT) based on informing tractography for diffusion-weighted images at 3T and by utilising the structure tensor obtained from gradient-recalled echo (GRE) images at 7T is able to delineate fibres when seed voxels are placed close to the fibre boundaries. However, incorporating data from two different field strengths limits the applicability of STIFT. In this study, STIFT was implemented with both diffusion-weighted images and GRE images acquired at ...[more]

PMID: 30030945

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Project description:Diffusion tensor tractography is increasingly used to examine structural connectivity in the brain in various conditions, but its test-retest reliability is understudied. The main purposes of this study were to evaluate 1) the reliability of quantitative measurements of diffusion tensor tractography and 2) the effect on reliability of the number of gradient sampling directions and scan repetition. Images were acquired from ten healthy participants. Ten fiber regions of nine major fiber tracts were reconstructed and quantified using six fiber variables. Intra- and inter-session reliabilities were estimated using intraclass correlation coefficient (ICC) and coefficient of variation (CV), and were compared to pinpoint major error sources. Additional pairwise comparisons were made between the reliability of images with 30 directions and NEX 2 (DTI30-2), 30 directions and NEX 1 (DTI30-1), and 15 directions and NEX 2 (DTI15-2) to determine whether increasing gradient directions and scan repetition improved reliability. Of the 60 tractography measurements, 43 showed intersession CV ? 10%, ICC ? .70, or both for DTI30-2, 40 measurements for DTI30-1, and 37 for DTI15-2. Most of the reliable measurements were associated with the tracts corpus callosum, cingulum, cerebral peduncular fibers, uncinate fasciculus, and arcuate fasciculus. These reliable measurements included factional anisotropy (FA) and mean diffusivity of all 10 fiber regions. Intersession reliability was significantly worse than intra-session reliability for FA, mean length, and tract volume measurements from DTI15-2, indicating that the combination of MRI signal variation and physiological noise/change over time was the major error source for this sequence. Increasing the number of gradient directions from 15 to 30 while controlling the scan time, significantly affected values for all six variables and reduced intersession variability for mean length and tract volume measurements. Additionally, while increasing scan repetition from 1 to 2 had no significant effect on the reliability for DTI with 30 directions, this significantly reduced the upward bias in FA values from all 10 fiber regions and fiber count, mean length, and tract volume measurements from 5 to 7 fiber regions. In conclusion, diffusion tensor tractography provided many measurements with high test-retest reliability across different fiber variables and various fiber tracts even for images with 15 directions (NEX 2). Increasing the number of gradient directions from 15 to 30 with equivalent scan time reduced variability whereas increasing repetition from 1 to 2 for 30-direction DTI improved the accuracy of tractography measurements.

Dataset Information

Structure tensor informed fibre tractography at 3T.

Publications

Structure tensor informed fibre tractography at 3T.

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