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Brain stimulation-induced neuroplasticity underlying therapeutic response in phantom sounds.

ABSTRACT: Noninvasive brain stimulation can modify phantom sounds for longer periods by modulating neural activity and putatively inducing regional neuroplastic changes. However, treatment response is limited and there are no good demographic or clinical predictors for treatment outcome. We used state-of-the-art voxel-based morphometry (VBM) to investigate whether transcranial magnetic stimulation-induced neuroplasticity determines therapeutic outcome. Sixty subjects chronically experiencing phantom sounds (i.e., tinnitus) received repetitive transcranial magnetic stimulation (rTMS) of left dorsolateral prefrontal and temporal cortex according to a protocol that has been shown to yield a significantly higher number of treatment responders than sham stimulation and previous stimulation protocols. Structural magnetic resonance imaging was performed before and after rTMS. In VBM whole-brain analyses (P?

SUBMITTER: Poeppl TB

PROVIDER: S-EPMC6866612 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Brain stimulation-induced neuroplasticity underlying therapeutic response in phantom sounds.

Poeppl Timm B TB Langguth Berthold B Lehner Astrid A Frodl Thomas T Rupprecht Rainer R Kreuzer Peter M PM Landgrebe Michael M Schecklmann Martin M

Human brain mapping 20171024 1

Noninvasive brain stimulation can modify phantom sounds for longer periods by modulating neural activity and putatively inducing regional neuroplastic changes. However, treatment response is limited and there are no good demographic or clinical predictors for treatment outcome. We used state-of-the-art voxel-based morphometry (VBM) to investigate whether transcranial magnetic stimulation-induced neuroplasticity determines therapeutic outcome. Sixty subjects chronically experiencing phantom sound ...[more]

PMID: 29064602

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