Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery.
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ABSTRACT:
SUBMITTER: Gano A
PROVIDER: S-EPMC6866658 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Rapid alterations in neuroimmune gene expression after acute ethanol: Timecourse, sex differences and sensitivity to cranial surgery.
Gano Anny A Mondello Jamie E JE Doremus-Fitzwater Tamara L TL Deak Terrence T
Journal of neuroimmunology 20191015
Prior work has established that that an acute ethanol challenge mimicking high intensity alcohol consumption increased IL-6 and suppressed IL-1β and TNFα mRNA in intoxication, with the opposite pattern seen in withdrawal. These experiments utilized Sprague-Dawley rats to further extend these results across time course (from 45 min to 6 h after ethanol), sex, and central versus peripheral expression. Furthermore, these data show that cannulation surgery may selectively modify the central neuroimm ...[more]
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