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Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function.

ABSTRACT: Stem cells are continuously challenged with the decision to either self-renew or adopt a new fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for differentiation. Previous studies have identified Polycomb group (PcG) and Trithorax group (TrxG) proteins as key modulators of cellular memory. In this Perspective, we draw from embryonic and adult stem cell studies to discuss the complex roles played by PcG and TrxG in maintaining cell identity while allowing for microenvironment-mediated alterations in cell fate. Finally, we discuss the potential for targeting these proteins as a therapeutic approach in cancer.

SUBMITTER: Brand M

PROVIDER: S-EPMC6866673 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function.

Brand Marjorie M Nakka Kiran K Zhu Jiayu J Dilworth F Jeffrey FJ

Cell stem cell 20190401 4

Stem cells are continuously challenged with the decision to either self-renew or adopt a new fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for differentiation. Previous studies have identified Polycomb group (PcG) and Trithorax group (TrxG) proteins as key modulators of cellular memory. In this Perspective, we draw from embryonic and adult stem cell studies to discuss the complex roles played by PcG and TrxG in maintaining cell identity while allowing for ...[more]

PMID: 30951661

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