Dataset Information

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder.

ABSTRACT:

Objectives

Although dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and their related neuronal patterns in individuals with PTSD at rest.

Methods

PTSD patients (N?=?57) and healthy controls (N?=?41) underwent resting-state fMRI. Connectivity patterns of key regions within the central autonomic network (CAN)-including the ventromedial prefrontal cortex (vmPFC), amygdala, and periaqueductal gray (PAG)-were examined using a seed-based approach. Observed connectivity patterns were then correlated to resting HRV.

Results

In contrast to controls, individuals with PTSD exhibited lower HRV. In addition, whereas controls engaged a localized connectivity pattern of CAN-related brain regions, in PTSD, key CAN regions were associated with widespread connectivity patterns in regions related to emotional reactivity (vmPFC and amygdala to insular cortex and lentiform nucleus; PAG to insula) and motor readiness (vmPFC and amygdala to precentral gyrus; PAG to precentral gyrus and cerebellum). Critically, whereas CAN connectivity in controls was strongly related to higher HRV (insula, mPFC, superior frontal cortex, thalamus), HRV covariation was absent in PTSD subjects.

Conclusions

This study provides the first evidence for a specific psychophysiological-neuronal profile in PTSD individuals characterized by lower resting HRV and a lack of HRV covariation with CAN-related brain connectivity. Hum Brain Mapp 38:27-40, 2017. © 2016 Wiley Periodicals, Inc.

SUBMITTER: Thome J

PROVIDER: S-EPMC6866719 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Publications

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder.

Thome Janine J Densmore Maria M Frewen Paul A PA McKinnon Margaret C MC Théberge Jean J Nicholson Andrew A AA Koenig Julian J Thayer Julian F JF Lanius Ruth A RA

Human brain mapping 20160920 1

<h4>Objectives</h4>Although dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and ...[more]

PMID: 27647521

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Dataset Information

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder.

Objectives

Methods

Results

Conclusions

Publications

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder.

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