Dataset Information

Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T1 -weighted MRI.

ABSTRACT: Magnetic resonance imaging (MRI) studies in humans have reported that the T1 -weighted signal in the cerebral cortex follows an inverted "U" trajectory over the lifespan. Here, we investigated the T1 -weighted signal trajectory from late adolescence to middle adulthood in humans to characterize the age range when mental illnesses tend to present, and efficacy of treatments are evaluated. We compared linear to quadratic predictors of age on signal in 67 healthy individuals, 17-45 years old. We investigated ¼, ½, and ¾ depths in the cortex representing intracortical myelin (ICM), in the superficial white matter (SWM), and in a reference deep white matter tract. We found that the quadratic fit was superior in all regions of the cortex, while signal in the SWM and deep white matter showed no global dependence on age over this range. The signal trajectory in any region followed a similar shape regardless of cortical depth. The quadratic fit was analyzed in 70 cortical regions to obtain the age of maximum signal intensity. We found that visual, cingulate, and left ventromedial prefrontal cortices peak first around 34 years old, whereas motor and premotor areas peak latest at ?38 years. Our analysis suggests that ICM trajectories over this range can be modeled well in small cohorts of subjects using quadratic functions, which are amenable to statistical analysis, thus suitable for investigating regional changes in ICM with disease. This study highlights a novel approach to map ICM trajectories using an age range that coincides with the onset of many mental illnesses. Hum Brain Mapp 38:3691-3703, 2017. © 2017 Wiley Periodicals, Inc.

SUBMITTER: Rowley CD

PROVIDER: S-EPMC6867063 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T1 -weighted MRI.

Rowley Christopher D CD Sehmbi Manpreet M Bazin Pierre-Louis PL Tardif Christine L CL Minuzzi Luciano L Frey Benicio N BN Bock Nicholas A NA

Human brain mapping 20170430 7

Magnetic resonance imaging (MRI) studies in humans have reported that the T1 -weighted signal in the cerebral cortex follows an inverted "U" trajectory over the lifespan. Here, we investigated the T1 -weighted signal trajectory from late adolescence to middle adulthood in humans to characterize the age range when mental illnesses tend to present, and efficacy of treatments are evaluated. We compared linear to quadratic predictors of age on signal in 67 healthy individuals, ...[more]

PMID: 28462512

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Project description:BackgroundReports on body mass index (BMI) trajectories from childhood into late adolescence, their determinants, and subsequent cardiometabolic risk markers, particularly among European populations have been few. Moreover, sex-specific investigation is necessary considering the sex difference in BMI, and the sex-specific association between BMI and some cardiometabolic risk markers.MethodsUsing a sample from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study, we explored sex-specific trajectories of the BMI standard deviation score (SDS) from 4 to 18 years of age in 354 males and 335 females by latent (class) growth models. The determinants of trajectory were assessed by logistic regression. We identified cardiometabolic risk markers that were highly associated with BMI SDS trajectory by random forest regression, and finally we used generalized linear models to investigate differences in the identified cardiometabolic risk markers between pairs of trajectories.ResultsWe observed four: 'low-normal weight', 'mid-normal weight', 'high-normal weight', and 'overweight', and three: ''low-normal weight', 'mid-normal weight', and 'high-normal weight' trajectories in males and females, respectively. Higher maternal prepregnancy BMI was associated with the 'overweight' trajectory, and with 'high-normal weight' trajectory in both sexes. In addition, employed mothers and first-born status were associated with 'high-normal weight' trajectory in females. BMI SDS trajectory was associated with high-density lipoprotein-cholesterol and interleukin-18 (IL-18) in males, and diastolic blood pressure and interleukin-6 (IL-6) in females. However, only males following the 'overweight' trajectory had significantly higher IL-18 when compared to their 'low-normal weight' counterpart.ConclusionsWe identified sex-specific distinct trajectories of BMI SDS from childhood into late adolescence, higher maternal prepregnancy BMI as a common determinant of the 'high-normal weight' and 'overweight' trajectories, and 'overweight' trajectory being associated with elevated IL-18 in late adolescence-young adulthood. This study emphasizes the role of maternal prepregnancy BMI in overweight, and highlights IL-18 as a cardiometabolic signature of overweight across life.

Project description:Different magnetic resonance (MR) parameters, such as R1 (=1/T1) or T2∗, have been used to visualize non-invasively the myelin distribution across the cortical sheet. Myelin contrast is consistently enhanced in the primary sensory and some higher order cortical areas (such as MT or the cingulate cortex), which renders it suitable for subject-specific anatomical cortical parcellation. However, no systematic comparison has been performed between the previously proposed MR parameters, i.e., the longitudinal and transversal relaxation values (or their ratios), for myelin mapping at 7 Tesla. In addition, usually these MR parameters are acquired in a non-quantitative manner ("weighted" parameters). Here, we evaluated the differences in 'parcellability,' contrast-to-noise ratio (CNR) and inter- and intra-subject variability and reproducibility, respectively, between high-resolution cortical surface maps based on these weighted MR parameters and their quantitative counterparts in ten healthy subjects. All parameters were obtained in a similar acquisition time and possible transmit- or receive-biases were removed during post-processing. It was found that CNR per unit time and parcellability were lower for the transversal compared to the longitudinal relaxation parameters. Further, quantitative R1 was characterized by the lowest inter- and intra-subject coefficient of variation (5.53 and 1.63%, respectively), making R1 a better parameter to map the myelin distribution compared to the other parameters. Moreover, quantitative MRI approaches offer the advantage of absolute rather than relative characterization of the underlying biochemical composition of the tissue, allowing more reliable comparison within subjects and between healthy subjects and patients. Finally, we explored two parcellation methods (thresholding the MR parameter values vs. surface gradients of these values) to determine areal borders based on the cortical surface pattern. It is shown that both methods are partially observer-dependent, needing manual interaction (i.e., choice of threshold or connecting high gradient values) to provide unambiguous borders.

Dataset Information

Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T1 -weighted MRI.

Publications

Age-related mapping of intracortical myelin from late adolescence to middle adulthood using T<sub>1</sub> -weighted MRI.

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