Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC6867347 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yang Xianfeng X Li Jin J Liu Bing B Li Yonghui Y Jiang Tianzi T
Human brain mapping 20160328 7
PICALM and CLU are two major risk genes of late-onset Alzheimer's disease (LOAD), and there is strong molecular evidence suggesting their interaction on amyloid-beta deposition, hence finding functional dependency between their risk genotypes may lead to better understanding of their roles in LOAD development and greater clinical utility. In this study, we mainly investigated interaction effects of risk loci PICALM rs3581179 and CLU rs11136000 on hippocampal degeneration in both young and elderl ...[more]