Dataset Information

Brain network dysregulation, emotion, and complaints after mild traumatic brain injury.

ABSTRACT:

Objectives

To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI).

Experimental design

Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within and between the default mode, executive (frontoparietal and bilateral frontal network), and salience network. The hospital anxiety and depression scale (HADS) was used to measure anxiety (HADS-A) and depression (HADS-D).

Principal observations

Regarding within-network functional connectivity, none of the selected brain networks were different between groups. Regarding between-network interactions, patients with complaints exhibited lower functional connectivity between the bilateral frontal and salience network compared to patients without complaints. In the total patient group, higher HADS-D scores were related to lower functional connectivity between the bilateral frontal network and both the right frontoparietal and salience network, and to higher connectivity between the right frontoparietal and salience network. Furthermore, whereas higher HADS-D scores were associated with lower connectivity within the parietal midline areas of the bilateral frontal network, higher HADS-A scores were related to lower connectivity within medial prefrontal areas of the bilateral frontal network.

Conclusions

Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.

SUBMITTER: van der Horn HJ

PROVIDER: S-EPMC6867381 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Publications

Brain network dysregulation, emotion, and complaints after mild traumatic brain injury.

van der Horn Harm J HJ Liemburg Edith J EJ Scheenen Myrthe E ME de Koning Myrthe E ME Marsman Jan-Bernard C JB Spikman Jacoba M JM van der Naalt Joukje J

Human brain mapping 20160205 4

<h4>Objectives</h4>To assess the role of brain networks in emotion regulation and post-traumatic complaints in the sub-acute phase after non-complicated mild traumatic brain injury (mTBI).<h4>Experimental design</h4>Fifty-four patients with mTBI (34 with and 20 without complaints) and 20 healthy controls (group-matched for age, sex, education, and handedness) were included. Resting-state fMRI was performed at four weeks post-injury. Static and dynamic functional connectivity were studied within ...[more]

PMID: 26846195

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Dataset Information

Brain network dysregulation, emotion, and complaints after mild traumatic brain injury.

Objectives

Experimental design

Principal observations

Conclusions

Publications

Brain network dysregulation, emotion, and complaints after mild traumatic brain injury.

Similar Datasets

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