Mathematical modeling of the glucagon challenge test.
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ABSTRACT:
SUBMITTER: Masroor S
PROVIDER: S-EPMC6868112 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Mathematical modeling of the glucagon challenge test.
Masroor Saeed S van Dongen Marloes G J MGJ Alvarez-Jimenez Ricardo R Burggraaf Koos K Peletier Lambertus A LA Peletier Mark A MA
Journal of pharmacokinetics and pharmacodynamics 20190930 6
A model for the homeostasis of glucose through the regulating hormones glucagon and insulin is described. It contains a subsystem that models the internalization of the glucagon receptor. Internalization is a mechanism in cell signaling, through which G-protein coupled receptors are taken from the surface of the cell to the endosome. The model is used to interpret data from a glucagon challenge test in which subjects have been under treatment with a novel glucagon receptor anti-sense drug which ...[more]
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