Airway epithelial regeneration requires autophagy and glucose metabolism.
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ABSTRACT:
SUBMITTER: Li K
PROVIDER: S-EPMC6868131 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Airway epithelial regeneration requires autophagy and glucose metabolism.
Li Kuan K Li Minmin M Li Wenli W Yu Hongzhi H Sun Xin X Zhang Qiuyang Q Li Yu Y Li Xue X Li Yue Y Abel E Dale ED Wu Qi Q Chen Huaiyong H
Cell death & disease 20191120 12
Efficient repair of injured epithelium by airway progenitor cells could prevent acute inflammation from progressing into chronic phase in lung. Here, we used small molecules, genetic loss-of-function, organoid cultures, and in vivo lung-injury models to show that autophagy is essential for maintaining the pool of airway stem-like vClub cells by promoting their proliferation during ovalbumin-induced acute inflammation. Mechanistically, impaired autophagy disrupted glucose uptake in vClub progenit ...[more]
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