Ontology highlight
ABSTRACT:
SUBMITTER: Park H
PROVIDER: S-EPMC6868140 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Park Hongryeol H Yamamoto Hiroyuki H Mohn Lucas L Ambühl Lea L Kanai Kenichi K Schmidt Inga I Kim Kee-Pyo KP Fraccaroli Alessia A Feil Silke S Junge Harald J HJ Montanez Eloi E Berger Wolfgang W Adams Ralf H RH
Nature communications 20191120 1
Familial exudative vitreoretinopathy (FEVR) is a human disease characterized by defective retinal angiogenesis and associated complications that can result in vision loss. Defective Wnt/β-catenin signaling is an established cause of FEVR, whereas other molecular alterations contributing to the disease remain insufficiently understood. Here, we show that integrin-linked kinase (ILK), a mediator of cell-matrix interactions, is indispensable for retinal angiogenesis. Inactivation of the murine Ilk ...[more]