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Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants.


ABSTRACT: BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and the Texas Birth Defects Registry (TBDR). METHODS:Using the TBDR, we identified 8,981 nonsyndromic isolated hypospadias cases from 1999 to 2008. Birth certificate controls were matched for birth year at a 10:1 ratio to cases. Estimated HAHAP concentrations from the 2005?U.S. EPA National-Scale Air Toxics Assessment were used to assign exposure based on maternal residence at birth. Exposure levels were categorized as quintiles based on the distribution in controls. Logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for each increasing exposure category of selected HAHAPs. RESULTS:Of the 10 HAHAPs studied, seven were significantly associated with hypospadias risk. The HAHAP that was most strongly associated with hypospadias was phenol, which was associated with risk in all groups except the high exposure group. Cumulative HAHAP exposure demonstrated a modest increase in hypospadias risk (OR 1.15, 95% CI: 1.07-1.24, p?

SUBMITTER: Sheth KR 

PROVIDER: S-EPMC6868530 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Hypospadias risk is increased with maternal residential exposure to hormonally active hazardous air pollutants.

Sheth Kunj R KR   Kovar Erin E   White Jeffrey T JT   Chambers Tiffany M TM   Peckham-Gregory Erin C EC   O'Neill Marisol M   Langlois Peter H PH   Seth Abhishek A   Scheurer Michael E ME   Lupo Philip J PJ   Jorgez Carolina J CJ  

Birth defects research 20190129 7


<h4>Background</h4>With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and the Texas Birth Defects Registry (TBDR).<h4>Methods</h4>Using the TBDR, we identified 8,981 nonsyndromic isolated hypospadias cases from 1999 to 2008. Birth certificate con  ...[more]

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