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Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as ¹⁸F-Labeled Positron Emission Tomography Probes via I-SPANC.

ABSTRACT: A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition reactions has been synthesized. These nitrone-AuNPs were characterized in detail using ¹H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone-AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.

SUBMITTER: Ghiassian S

PROVIDER: S-EPMC6868604 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18F-Labeled Positron Emission Tomography Probes via I-SPANC.

Ghiassian Sara S Yu Lihai L Gobbo Pierangelo P Nazemi Ali A Romagnoli Tommaso T Luo Wilson W Luyt Leonard G LG Workentin Mark S MS

ACS omega 20191108 21

A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition reactions has been synthesized. These nitrone-AuNPs were characterized in detail using 1H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conj ...[more]

PMID: 31763533

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