Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer.
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ABSTRACT:
SUBMITTER: Shemesh CS
PROVIDER: S-EPMC6868826 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer.
Shemesh Colby S CS Chanu Pascal P Jamsen Kris K Wada Russ R Rossato Gianluca G Donaldson Francis F Garg Amit A Winter Helen H Ruppel Jane J Wang Xin X Bruno Rene R Jin Jin J Girish Sandhya S
Journal for immunotherapy of cancer 20191121 1
<h4>Background</h4>The iMATRIX-atezolizumab study was a phase I/II, multicenter, open-label study designed to assess the safety and pharmacokinetics of atezolizumab in pediatric and young adult patients. We describe the pharmacokinetics (PK), exposure-safety, and immunogenicity of atezolizumab in pediatric and young adults with metastatic solid tumors or hematologic malignancies enrolled in this study.<h4>Methods</h4>Patients aged < 18 years (n = 69) received a weight-adjusted dose of atezolizum ...[more]
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