Dopaminergic correlates of metabolic network activity in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Holtbernd F
PROVIDER: S-EPMC6869564 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Dopaminergic correlates of metabolic network activity in Parkinson's disease.
Holtbernd Florian F Ma Yilong Y Peng Shichun S Schwartz Frank F Timmermann Lars L Kracht Lutz L Fink Gereon R GR Tang Chris C CC Eidelberg David D Eggers Carsten C
Human brain mapping 20150603 9
Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate to the motor and cognitive manifestations of the disorder. It is not known, however, how the expression of these patterns relates to measurements of nigrostriatal dopaminergic activity from the same individuals. To explore these associations, we studied 106 PD subjects who underwent cerebral PET with both (18) F-fluorodeoxyglucose (FDG) and (18) F-fluoro-L-dopa (FDOPA). Expression values for the PD mot ...[more]
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