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COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder.


ABSTRACT: Increased dopamine availability may be associated with impaired structural maturation of brain white matter connectivity. This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal connectivity differences in attention-deficit/hyperactivity disorder (ADHD) associated with catechol-O-methyltransferase gene (COMT) Val158Met polymorphism. Using diffusion tensor imaging, whole-brain tractography, and an imaging connectomics approach, we characterized altered white matter connectivity in youth with ADHD who were COMT Val-homozygous (N?=?29) compared with those who were Met-carriers (N?=?29). Additionally, we examined whether dopamine transporter gene (DAT1) and dopamine D4 receptor gene (DRD4) polymorphisms were associated with white matter differences. Level of attention was assessed using the continuous performance test before and after an 8-week open-label trial of methylphenidate (MPH). A network of white matter connections linking 18 different brain regions was significantly weakened in youth with ADHD who were COMT Met-carriers compared to those who were Val-homozygous (P?

SUBMITTER: Hong SB 

PROVIDER: S-EPMC6869623 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder.

Hong Soon-Beom SB   Zalesky Andrew A   Park Subin S   Yang Young-Hui YH   Park Min-Hyeon MH   Kim BoAh B   Song In-Chan IC   Sohn Chul-Ho CH   Shin Min-Sup MS   Kim Bung-Nyun BN   Cho Soo-Churl SC   Kim Jae-Won JW  

Human brain mapping 20140909 1


Increased dopamine availability may be associated with impaired structural maturation of brain white matter connectivity. This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal connectivity differences in attention-deficit/hyperactivity disorder (ADHD) associated with catechol-O-methyltransferase gene (COMT) Val158Met polymorphism. Using diffusion tensor imaging, whole-brain tractography, and an imaging connectomics approach, we characterized altered white  ...[more]

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