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Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.

ABSTRACT: This study presents a meta-analysis comparing hit and correct rejection (CR) conditions across 48 fMRI studies. Old/new (hit > CR) effects associated most consistently with (1) components of the default-mode network, including the left angular gyrus, bilateral precuneus, and bilateral posterior cingulate regions, which may support the mental re-experiencing of an old event, or ecphory; (2) components of the cognitive-control network, involving the left dorsolateral and dorsomedial prefrontal cortex and bilateral intraparietal sulcus regions, which may mediate memory and non-memory control functions; and (3) the caudate nucleus, a key part of the brain's reward system that may support the satisfaction tied to target-detection. Direct comparisons of old/new effects between item versus source retrieval and "remember" versus "know" retrieval yielded three main sets of findings. First, default-mode network regions showed greater old/new effects in conditions associated with richer ecphoric processing. Second, cognitive-control network regions showed greater old/new effects in conditions associated with a greater demand for strategic-retrieval processing. Third, the caudate nucleus showed greater old/new effects in conditions tied to greater confidence in target-detection. New/old (CR > hit) effects most strongly associated with the bilateral medial temporal lobe, possibly reflecting greater encoding-related activity for new than for old items, and the right posterior middle temporal regions, possibly reflecting repetition-related neural priming for old items. In conclusion, neural activity distinguishing old from new events comprises an ensemble of multiple memory-specific activities, including encoding, retrieval, and priming, as well as multiple types of more general cognitive activities, including default-mode, cognitive-control, and reward processing.

SUBMITTER: Kim H

PROVIDER: S-EPMC6870306 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.

Kim Hongkeun H

Human brain mapping 20111123 4

This study presents a meta-analysis comparing hit and correct rejection (CR) conditions across 48 fMRI studies. Old/new (hit > CR) effects associated most consistently with (1) components of the default-mode network, including the left angular gyrus, bilateral precuneus, and bilateral posterior cingulate regions, which may support the mental re-experiencing of an old event, or ecphory; (2) components of the cognitive-control network, involving the left dorsolateral and dorsomedial prefrontal cor ...[more]

PMID: 22110008

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Project description:Parkinsonism is a feature of several neurodegenerative disorders, including Parkinson's disease, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. Neuroimaging studies have yielded insights into parkinsonian disorders; however, due to variability in results, the brain regions consistently implicated in these disorders remain to be characterized. The aim of this meta-analysis was to identify consistent brain abnormalities in individual parkinsonian disorders (Parkinson's disease, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy) and to investigate any shared abnormalities across disorders. A total of 44 591 studies were systematically screened following searches of two databases. A series of whole-brain activation likelihood estimation meta-analyses were performed on 132 neuroimaging studies (69 Parkinson's disease; 23 progressive supranuclear palsy; 17 corticobasal syndrome; and 23 multiple system atrophy) utilizing anatomical MRI, perfusion or metabolism PET and single-photon emission computed tomography. Meta-analyses were performed in each parkinsonian disorder within each imaging modality, as well as across all included disorders. Results in progressive supranuclear palsy and multiple system atrophy aligned with current imaging markers for diagnosis, encompassing the midbrain, and brainstem and putamen, respectively. PET imaging studies of patients with Parkinson's disease most consistently reported abnormality of the middle temporal gyrus. No significant clusters were identified in corticobasal syndrome. When examining abnormalities shared across all four disorders, the caudate was consistently reported in MRI studies, whilst the thalamus, inferior frontal gyrus and middle temporal gyri were commonly implicated by PET. To our knowledge, this is the largest meta-analysis of neuroimaging studies in parkinsonian disorders and the first to characterize brain regions implicated across parkinsonian disorders.

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Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.

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Differential neural activity in the recognition of old versus new events: an activation likelihood estimation meta-analysis.

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