Ontology highlight
ABSTRACT:
SUBMITTER: Ahlers LRH
PROVIDER: S-EPMC6871768 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ahlers Laura R H LRH Trammell Chasity E CE Carrell Grace F GF Mackinnon Sophie S Torrevillas Brandi K BK Chow Clement Y CY Luckhart Shirley S Goodman Alan G AG
Cell reports 20191101 7
The World Health Organization estimates that more than half of the world's population is at risk for vector-borne diseases, including arboviruses. Because many arboviruses are mosquito borne, investigation of the insect immune response will help identify targets to reduce the spread of arboviruses. Here, we use a genetic screening approach to identify an insulin-like receptor as a component of the immune response to arboviral infection. We determine that vertebrate insulin reduces West Nile viru ...[more]