Ontology highlight
ABSTRACT:
SUBMITTER: Soto F
PROVIDER: S-EPMC6871773 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Soto Florentina F Tien Nai-Wen NW Goel Anurag A Zhao Lei L Ruzycki Philip A PA Kerschensteiner Daniel D
Cell reports 20191101 6
The size of dendrite arbors shapes their function and differs vastly between neuron types. The signals that control dendritic arbor size remain obscure. Here, we find that in the retina, starburst amacrine cells (SACs) and rod bipolar cells (RBCs) express the homophilic cell-surface protein AMIGO2. In Amigo2 knockout (KO) mice, SAC and RBC dendrites expand while arbors of other retinal neurons remain stable. SAC dendrites are divided into a central input region and a peripheral output region tha ...[more]