Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6872576 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Wang Ying Y Sherrard Alice A Zhao Bing B Melak Michael M Trautwein Jonathan J Kleinschnitz Eva-Maria EM Tsopoulidis Nikolaos N Fackler Oliver T OT Schwan Carsten C Grosse Robert R
Nature communications 20191121 1
Although the properties of the actin cytoskeleton in the cytoplasm are well characterized, the regulation and function of nuclear actin filaments are only recently emerging. We previously demonstrated serum-induced, transient assembly of filamentous actin within somatic cell nuclei. However, the extracellular cues, cell surface receptors as well as underlying signaling mechanisms have been unclear. Here we demonstrate that physiological ligands for G protein-coupled receptors (GPCRs) promote nuc ...[more]