Ontology highlight
ABSTRACT:
SUBMITTER: Obermayer J
PROVIDER: S-EPMC6872593 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Obermayer Joshua J Luchicchi Antonio A Heistek Tim S TS de Kloet Sybren F SF Terra Huub H Bruinsma Bastiaan B Mnie-Filali Ouissame O Kortleven Christian C Galakhova Anna A AA Khalil Ayoub J AJ Kroon Tim T Jonker Allert J AJ de Haan Roel R van de Berg Wilma D J WDJ Goriounova Natalia A NA de Kock Christiaan P J CPJ Pattij Tommy T Mansvelder Huibert D HD
Nature communications 20191121 1
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC). Both interneurons in layers (L)1-3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP ne ...[more]