Ontology highlight
ABSTRACT:
SUBMITTER: Cancer M
PROVIDER: S-EPMC6872649 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Čančer Matko M Drews Lisa F LF Bengtsson Johan J Bolin Sara S Rosén Gabriela G Westermark Bengt B Nelander Sven S Forsberg-Nilsson Karin K Uhrbom Lene L Weishaupt Holger H Swartling Fredrik J FJ
Cell death & disease 20191121 12
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Patients usually undergo surgery followed by aggressive radio- and chemotherapy with the alkylating agent temozolomide (TMZ). Still, median survival is only 12-15 months after diagnosis. Many human cancers including GBMs demonstrate addiction to MYC transcription factor signaling and can become susceptible to inhibition of MYC downstream genes. JQ1 is an effective inhibitor of BET Bromodomains, a class of e ...[more]