Ontology highlight
ABSTRACT:
SUBMITTER: Juni RP
PROVIDER: S-EPMC6872802 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Juni Rio P RP Kuster Diederik W D DWD Goebel Max M Helmes Michiel M Musters René J P RJP van der Velden Jolanda J Koolwijk Pieter P Paulus Walter J WJ van Hinsbergh Victor W M VWM
JACC. Basic to translational science 20190904 5
The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empagliflozin on the heart. These patients frequently have HF with preserved ejection fraction (HFpEF), in which a metabolic risk-related pro-inflammatory state induces cardiac microvascular endothelial cell (CMEC) dysfunction with subsequent cardiomyocyte (CM) contract ...[more]