Early life growth and adult telomere length in a Filipino cohort study.

ABSTRACT:

Objective

We investigated the relationship between early life growth patterns and blood telomere length (TL) in adulthood using conditional measures of lean and fat mass growth to evaluate potentially sensitive periods of early life growth.

Methods

This study included data from 1562 individuals (53% male; age 20-22 years) participating in the Cebu Longitudinal Health and Nutrition Survey, located in metropolitan Cebu, Philippines. Primary exposures included length-for-age z-score (HAZ) and weight-for-age z-score (WAZ) at birth and conditional measures of linear growth and weight gain during four postnatal periods: 0-6, 6-12, and 12-24 months, and 24 months to 8.5 years. TL was measured at ~21 years of age. We estimated associations using linear regression.

Results

The

SUBMITTER: Masterson EE 

PROVIDER: S-EPMC6872908 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature