Five-year real-world outcomes of anti-vascular endothelial growth factor monotherapy versus combination therapy for polypoidal choroidal vasculopathy in a Chinese population: a retrospective study.

ABSTRACT: BACKGROUND:To evaluate 5-year outcomes of anti-vascular endothelial growth factor (VEGF) monotherapy and combination therapy of anti-VEGF agents and photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) in a real-world Chinese population. METHODS:Retrospective study. Fifty-three eyes of 46 patients with subtype 1 and 2 PCV followed up for at least 60?months were grouped into three regimens: anti-VEGF monotherapy, PDT combining with anti-VEGF therapy initially, and PDT combining with deferred anti-VEGF therapy. Main outcome measure was best-corrected visual acuity (BCVA) using logarithm of minimal angle of resolution (logMAR). RESULTS:The mean BCVA of eyes with subtype 1 PCV (n?=?28) deteriorated from 0.69 logMAR at baseline to 1.25 logMAR at months 60 (P?=?0.001), while the mean BCVA of eyes with subtype 2 PCV (n?=?25) sustained stable from 0.62 logMAR at baseline to 0.57 at months 60 (P?=?0.654). No significant differences of visual outcomes were found between the 3 treatment regimens for subtype 1 PCV. Anti-VEGF monotherapy and initial combination treatment had better visual outcomes in eyes with subtype 2 PCV than deferred combination group during part of follow-up significantly. Initial combination group needed a less number of PDT than deferred combination group (P?

SUBMITTER: Yang J 

PROVIDER: S-EPMC6873695 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature