Association between lncRNA H19 rs217727 polymorphism and the risk of cancer: an updated meta-analysis.

ABSTRACT: BACKGROUND:We have performed this study to evaluate the association between H19 rs217727 polymorphism and the risk of cancer. METHODS:An odds ratio (OR) with a 95% confidence interval (CI) was applied to determine a potential association. RESULTS:A total of 17 case-control publications were selected. This meta-analysis showed that H19 rs217727 has a significant increased association with cancer risk in allelic, homozygous, heterozygote, dominant and recessive models (T vs C: OR?=?1.16, 95% CI?=?1.06-1.27, I2?=?75.7; TT vs CC: OR?=?1.29, 95% CI?=?1.06-1.56, I2?=?71.6; CT vs CC: OR?=?1.15, 95% CI?=?1.01-1.31, I2?=?75.4; CT?+?TT vs CC: OR?=?1.20, 95% CI?=?1.05-1.36, I2?=?76.5; TT vs CT?+?CC: OR?=?1.22, 95% CI?=?1.02-1.45, I2?=?70.6;). In the subgroup analysis of smoking status, both smokers and nonsmokers showed an increase in cancer risk in allelic, homozygous, dominant and heterozygote models. CONCLUSION:This meta-analysis revealed H19 rs217727 may influence cancer susceptibility.

SUBMITTER: Wang X 

PROVIDER: S-EPMC6873771 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature