Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance.
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ABSTRACT:
SUBMITTER: Nogueira JCF
PROVIDER: S-EPMC6873773 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Oriented attachment of V<sub>NAR</sub> proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance.
Nogueira João C F JCF Greene Michelle K MK Richards Daniel A DA Furby Alexander O AO Steven John J Porter Andrew A Barelle Caroline C Scott Christopher J CJ Chudasama Vijay V
Chemical communications (Cambridge, England) 20190601 53
Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) nanoparticles to delta like canonical Notch ligand 4 (DLL4). The importance of site-specific chemistry is demonstrated. ...[more]
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