Dataset Information

MERS-CoV in Camels but Not Camel Handlers, Sudan, 2015 and 2017.

ABSTRACT: We tested samples collected from camels, camel workers, and other animals in Sudan and Qatar in 2015 and 2017 for evidence of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. MERS-CoV antibodies were abundant in Sudan camels, but we found no evidence of MERS-CoV infection in camel workers, other livestock, or bats.

SUBMITTER: Farag E

PROVIDER: S-EPMC6874263 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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MERS-CoV in Camels but Not Camel Handlers, Sudan, 2015 and 2017.

Farag Elmoubasher E Sikkema Reina S RS Mohamedani Ahmed A AA de Bruin Erwin E Munnink Bas B Oude BBO Chandler Felicity F Kohl Robert R van der Linden Anne A Okba Nisreen M A NMA Haagmans Bart L BL van den Brand Judith M A JMA Elhaj Asia Mohamed AM Abakar Adam D AD Nour Bakri Y M BYM Mohamed Ahmed M AM Alwaseela Bader Eldeen BE Ahmed Husna H Alhajri Mohd Mohd MM Koopmans Marion M Reusken Chantal C Elrahman Samira Hamid Abd SHA

Emerging infectious diseases 20191201 12

We tested samples collected from camels, camel workers, and other animals in Sudan and Qatar in 2015 and 2017 for evidence of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. MERS-CoV antibodies were abundant in Sudan camels, but we found no evidence of MERS-CoV infection in camel workers, other livestock, or bats. ...[more]

PMID: 31742534

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Project description:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging viral disease and dromedary camels are known to be the source of human spill over events. A cross-sectional epidemiological surveillance study was carried out in Kenya in 2017 to, 1) estimate MERS-CoV antibody seropositivity in the camel-dense counties of Turkana, Marsabit, Isiolo, Laikipia and Nakuru to identify, and 2) determine the risk factors associated with seropositivity in camels. Blood samples were collected from a total of 1421 camels selected using a multi-stage sampling method. Data were also collected from camel owners or herders using a pre-tested structured questionnaire. The sera from camel samples were tested for the presence of circulating antibodies to MERS-CoV using the anti-MERS-CoV IgG ELISA test. Univariate and multivariable statistical analysis were used to investigate factors potentially associated with MERS-CoV seropositivity in camels. The overall seropositivity in camel sera was 62.9 %, with the highest seropositivity recorded in Isiolo County (77.7 %), and the lowest seropositivity recorded in Nakuru County (14.0 %). When risk factors for seropositivity were assessed, the "Type of camel production system" {(aOR = 5.40(95 %CI: 1.67-17.49)}, "Age between 1-2 years, 2-3 years and above 3 years" {(aOR = 1.64 (95 %CI: 1.04-2.59}", {(aOR = 3.27 (95 %CI: 3.66-5.61)}" and {(aOR = 6.12 (95 %CI: 4.04-9.30)} respectively and "Sex of camels" {(aOR = 1.75 (95 %CI: 1.27-2.41)} were identified as significant predictors of MERS-CoV seropositivity. Our studies indicate a high level of seropositivity to MERS-CoV in camels in the counties surveyed, and highlights the important risk factors associated with MERS-CoV seropositivity in camels. Given that MERS-CoV is a zoonosis, and Kenya possesses the fourth largest camel population in Africa, these findings are important to inform the development of efficient and risk-based prevention and mitigation strategies against MERS-CoV transmission to humans.

Dataset Information

MERS-CoV in Camels but Not Camel Handlers, Sudan, 2015 and 2017.

Publications

MERS-CoV in Camels but Not Camel Handlers, Sudan, 2015 and 2017.

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