Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics.
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ABSTRACT:
SUBMITTER: Hicks AL
PROVIDER: S-EPMC6874359 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics.
Hicks Allison L AL Kissler Stephen M SM Lipsitch Marc M Grad Yonatan H YH
PLoS biology 20191112 11
The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and alleles that lead to resistance. As novel resistance variants are expected to emerge, such sensitivity is expected to decline unless the new variants are detected and incorporated into the diagnostic. Here, we present a mathematical framework to define how many diagnostic failures may be expected under varying surveillance regimes and thus quantify the s ...[more]
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