Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC6874410 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhang Fusong F Lai Qi Q Shi Xiaodong X Song Zhiguang Z
Chinese chemical letters = Zhongguo hua xue kuai bao 20180524 2
A gold-catalyzed three-component coupling reaction (A3 reaction) was developed as an efficient approach for the synthesis of challenging 2, 4-disubstituted quinoline derivatives. Compared to previously reported Cu/Au bi-catalyst system, this protocol enables achieving A3 reaction only in the presence of triazole-gold catalyst. Notably, 4-alkyl substituted or 2-alkyl substituted quinoline derivatives were obtained with good yields, which highlighted the unique advantage of this new strategy. ...[more]