Ontology highlight
ABSTRACT:
SUBMITTER: Thomson BR
PROVIDER: S-EPMC6874417 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Thomson Benjamin R BR Carota Isabel A IA Souma Tomokazu T Soman Saily S Vestweber Dietmar D Quaggin Susan E SE
eLife 20191017
Elevated intraocular pressure (IOP) due to insufficient aqueous humor outflow through the trabecular meshwork and Schlemm's canal (SC) is the most important risk factor for glaucoma, a leading cause of blindness worldwide. We previously reported loss of function mutations in the receptor tyrosine kinase TEK or its ligand ANGPT1 cause primary congenital glaucoma in humans and mice due to failure of SC development. Here, we describe a novel approach to enhance canal formation in these animals by d ...[more]