LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.
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ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC6874432 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.
Song Honghai H Liu Jiaming J Wu Xin X Zhou Yang Y Chen Xuanyin X Chen Jiangwei J Deng Keyu K Mao Chunxia C Huang Shanhu S Liu Zhili Z
Aging 20191113 21
The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. LHX2 overexpression could restore the malignant phenotypes. In conclusion, LHX2 regulates tumorigenesis and autophagy via ...[more]
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