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Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

ABSTRACT: Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression correlates with clinical stages of osteosarcoma. The adipokine resistin exhibits proinflammatory, proangiogenic and metastatic properties, and evidence suggests that resistin may serve as a prognostic biomarker linking obesity and inflammation to cancer. However, whether resistin has a role in osteosarcoma angiogenesis is unclear. This investigation shows that resistin promotes VEGF-A expression in human osteosarcoma cells and activates the extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 signaling pathways, while ERK, JNK, and p38 inhibitors or their small interfering RNAs (siRNAs) inhibit resistin-induced VEGF-A expression as well as endothelial progenitor cell (EPC) migration and tube formation. We also found that resistin upregulates VEGF-A expression by enhancing activation of the transcription factor nuclear factor-kappa B (NF-?B). Finally, resistin promotes angiogenesis in the chick chorioallantoic membrane (CAM) model. Resistin appears to be a promising target for human osteosarcoma.

SUBMITTER: Tsai HC

PROVIDER: S-EPMC6874472 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

Tsai Hsiao-Chi HC Cheng Shih-Ping SP Han Chien-Kuo CK Huang Yuan-Li YL Wang Shih-Wei SW Lee Jie-Jen JJ Lai Cheng-Ta CT Fong Yi-Chin YC Tang Chih-Hsin CH

Aging 20191113 21

Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression correlates with clinical stages of osteosarcoma. The adipokine resistin exhibits proinflammatory, proangiogenic and metastatic properties, and evidence suggests that resistin may serve ...[more]

PMID: 31719210

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Dataset Information

Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

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Resistin enhances angiogenesis in osteosarcoma via the MAPK signaling pathway.

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