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Genomic and epidemiological monitoring of yellow fever virus transmission potential.

ABSTRACT: The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

SUBMITTER: Faria NR 

PROVIDER: S-EPMC6874500 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Genomic and epidemiological monitoring of yellow fever virus transmission potential.

Faria N R NR   Kraemer M U G MUG   Hill S C SC   Goes de Jesus J J   Aguiar R S RS   Iani F C M FCM   Xavier J J   Quick J J   du Plessis L L   Dellicour S S   Thézé J J   Carvalho R D O RDO   Baele G G   Wu C-H CH   Silveira P P PP   Arruda M B MB   Pereira M A MA   Pereira G C GC   Lourenço J J   Obolski U U   Abade L L   Vasylyeva T I TI   Giovanetti M M   Yi D D   Weiss D J DJ   Wint G R W GRW   Shearer F M FM   Funk S S   Nikolay B B   Fonseca V V   Adelino T E R TER   Oliveira M A A MAA   Silva M V F MVF   Sacchetto L L   Figueiredo P O PO   Rezende I M IM   Mello E M EM   Said R F C RFC   Santos D A DA   Ferraz M L ML   Brito M G MG   Santana L F LF   Menezes M T MT   Brindeiro R M RM   Tanuri A A   Dos Santos F C P FCP   Cunha M S MS   Nogueira J S JS   Rocco I M IM   da Costa A C AC   Komninakis S C V SCV   Azevedo V V   Chieppe A O AO   Araujo E S M ESM   Mendonça M C L MCL   Dos Santos C C CC   Dos Santos C D CD   Mares-Guia A M AM   Nogueira R M R RMR   Sequeira P C PC   Abreu R G RG   Garcia M H O MHO   Abreu A L AL   Okumoto O O   Kroon E G EG   de Albuquerque C F C CFC   Lewandowski K K   Pullan S T ST   Carroll M M   de Oliveira T T   Sabino E C EC   Souza R P RP   Suchard M A MA   Lemey P P   Trindade G S GS   Drumond B P BP   Filippis A M B AMB   Loman N J NJ   Cauchemez S S   Alcantara L C J LCJ   Pybus O G OG  

Science (New York, N.Y.) 20180823 6405

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian <i>Aedes</i> species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generat  ...[more]

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