Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice.
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ABSTRACT:
SUBMITTER: Reyes-Caballero H
PROVIDER: S-EPMC6874681 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Air pollution-derived particulate matter dysregulates hepatic Krebs cycle, glucose and lipid metabolism in mice.
Reyes-Caballero Hermes H Rao Xiaoquan X Sun Qiushi Q Warmoes Marc O MO Lin Penghui P Sussan Tom E TE Park Bongsoo B Fan Teresa W-M TW Maiseyeu Andrei A Rajagopalan Sanjay S Girnun Geoffrey D GD Biswal Shyam S
Scientific reports 20191122 1
Exposure to ambient air particulate matter (PM<sub>2.5</sub>) is well established as a risk factor for cardiovascular and pulmonary disease. Both epidemiologic and controlled exposure studies in humans and animals have demonstrated an association between air pollution exposure and metabolic disorders such as diabetes. Given the central role of the liver in peripheral glucose homeostasis, we exposed mice to filtered air or PM<sub>2.5</sub> for 16 weeks and examined its effect on hepatic metabolic ...[more]
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