Ontology highlight
ABSTRACT:
SUBMITTER: Smith CC
PROVIDER: S-EPMC6874891 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Smith Christof C CC Selitsky Sara R SR Chai Shengjie S Armistead Paul M PM Vincent Benjamin G BG Serody Jonathan S JS
Nature reviews. Cancer 20190705 8
The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has accelerated within the past decade. The most commonly studied class of TSAs are those derived from non-synonymous single-nucleotide variants (SNVs), or SNV neoantigens. However, to increase the repertoire of available therapeutic TSA targets, 'alternative TSAs', defined here as high-specificity tumour antigens arising from non-SNV genomic sources, have recently been evaluated. Among these alternative TSAs are an ...[more]