Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto J
PROVIDER: S-EPMC6876247 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Miyamoto Junki J Ohue-Kitano Ryuji R Mukouyama Hiromi H Nishida Akari A Watanabe Keita K Igarashi Miki M Irie Junichiro J Tsujimoto Gozoh G Satoh-Asahara Noriko N Itoh Hiroshi H Kimura Ikuo I
Proceedings of the National Academy of Sciences of the United States of America 20191104 47
Ketone bodies, including β-hydroxybutyrate and acetoacetate, are important alternative energy sources during energy shortage. β-Hydroxybutyrate also acts as a signaling molecule via specific G protein-coupled receptors (GPCRs); however, the specific associated GPCRs and physiological functions of acetoacetate remain unknown. Here we identified acetoacetate as an endogenous agonist for short-chain fatty acid (SCFA) receptor GPR43 by ligand screening in a heterologous expression system. Under keto ...[more]