Ontology highlight
ABSTRACT:
SUBMITTER: Esposito E
PROVIDER: S-EPMC6876639 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Esposito Elga E Ahn Bum Ju BJ Shi Jingfei J Nakamura Yoshihiko Y Park Ji Hyun JH Mandeville Emiri T ET Yu Zhanyang Z Chan Su Jing SJ Desai Rakhi R Hayakawa Ayumi A Ji Xunming X Lo Eng H EH Hayakawa Kazuhide K
Nature communications 20191122 1
After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferate and macrophages are rapidly activated in CLNs within 24 h, in part via VEGF-C/VEGFR3 signalling. Microarray analyses of isolated lymphati ...[more]