Ontology highlight
ABSTRACT:
SUBMITTER: Cloux AJ
PROVIDER: S-EPMC6877101 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cloux Anne-Julie AJ Aubry Dominique D Heulot Mathieu M Widmann Christian C ElMokh Oussama O Piacente Francesco F Cea Michele M Nencioni Alessio A Bellotti Axel A Bouzourène Karima K Pellegrin Maxime M Mazzolai Lucia L Duchosal Michel A MA Nahimana Aimable A
Oncotarget 20191119 62
APO866 is a small molecule drug that specifically inhibits nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis from the natural precursor nicotinamide. Although, the antitumor activity of APO866 on various types of cancer models has been reported, information regarding mechanisms by which APO866 exerts its cytotoxic effects is not well defined. Here we show that APO866 induces a strong, time-dependent increase in highly re ...[more]