Ontology highlight
ABSTRACT:
SUBMITTER: Hocher A
PROVIDER: S-EPMC6877293 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
eLife 20191111
Histones are a principal constituent of chromatin in eukaryotes and fundamental to our understanding of eukaryotic gene regulation. In archaea, histones are widespread but not universal: several lineages have lost histone genes. What prompted or facilitated these losses and how archaea without histones organize their chromatin remains largely unknown. Here, we elucidate primary chromatin architecture in an archaeon without histones, <i>Thermoplasma acidophilum,</i> which harbors a HU family prot ...[more]