Ontology highlight
ABSTRACT:
SUBMITTER: Houweling AC
PROVIDER: S-EPMC6877301 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Houweling Arjan C AC Beaman Glenda M GM Postma Alex V AV Gainous T Blair TB Lichtenbelt Klaske D KD Brancati Francesco F Lopes Filipa M FM van der Made Ingeborg I Polstra Abeltje M AM Robinson Michael L ML Wright Kevin D KD Ellingford Jamie M JM Jackson Ashley R AR Overwater Eline E Genesio Rita R Romano Silvio S Camerota Letizia L D'Angelo Emanuela E Meijers-Heijboer Elizabeth J EJ Christoffels Vincent M VM McHugh Kirk M KM Black Brian L BL Newman William G WG Woolf Adrian S AS Creemers Esther E EE
The Journal of clinical investigation 20191201 12
Myocardin (MYOCD) is the founding member of a class of transcriptional coactivators that bind the serum-response factor to activate gene expression programs critical in smooth muscle (SM) and cardiac muscle development. Insights into the molecular functions of MYOCD have been obtained from cell culture studies, and to date, knowledge about in vivo roles of MYOCD comes exclusively from experimental animals. Here, we defined an often lethal congenital human disease associated with inheritance of p ...[more]