Ontology highlight
ABSTRACT:
SUBMITTER: Tan P
PROVIDER: S-EPMC6877338 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Tan Peng P He Lian L Xing Changsheng C Mao Jingrong J Yu Xiao X Zhu Motao M Diao Lixia L Han Leng L Zhou Yubin Y You M James MJ Wang Helen Y HY Wang Rong-Fu RF
The Journal of clinical investigation 20191201 12
Beclin 1 (Becn1) is a key molecule in the autophagy pathway and has been implicated in cancer development. Due to the embryonic lethality of homozygous Becn1-deficient mice, the precise mechanisms and cell type-specific roles of Becn1 in regulating inflammation and cancer immunity remain elusive. Here, we report that myeloid-deficient Becn1 (Becn1ΔM) mice developed neutrophilia, were hypersusceptible to LPS-induced septic shock, and had a high risk of developing spontaneous precursor B cell (pre ...[more]