Molecular and Clinicopathological Features of Gastrointestinal Stromal Tumors in Vietnamese Patients.

ABSTRACT:

Background

Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract. Management of GIST patients is currently based on clinicopathological features and associated genetic changes. However, the detailed characteristics and molecular genetic features of GISTs have not yet been described in the Vietnamese population.

Methods

We first identified 155 patients with primary GIST who underwent surgery with primary curative intent between 2011 and 2014 at University Medical Center at Ho Chi Minh City, Vietnam. We evaluated the clinicopathological features and immunohistochemical reactivity to p53 and Ki-67 in these patients. Additionally, KIT genotyping was performed in 100 cases.

Results

The largest proportion of GISTs

SUBMITTER: Ngo QD 

PROVIDER: S-EPMC6877433 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature