BID and the ?-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
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ABSTRACT:
SUBMITTER: Rigo A
PROVIDER: S-EPMC6877650 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
Rigo Antonella A Ferrarini Isacco I Lorenzetto Erika E Darra Elena E Liparulo Irene I Bergamini Christian C Sissa Cinzia C Cavalieri Elisabetta E Vinante Fabrizio F
Cell death & disease 20191126 12
α-Bisabolol (BSB) is a plant-derived sesquiterpene alcohol able to trigger regulated cell death in transformed cells, while deprived of the general toxicity in several mouse models. Here, we investigated the involvement of lysosomal and mitochondrial compartments in the cytotoxic effects of BSB, with a specific focus on the BH3-only activator protein BID. We found that BSB particularly accumulated in cancer cell lines, displaying a higher amount of lipid rafts as compared to normal blood cells. ...[more]
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