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Modeling of Brain-Like Concept Coding with Adulthood Neurogenesis in the Dentate Gyrus.

ABSTRACT: Mammalian brains respond to new concepts via a type of neural coding termed "concept coding." During concept coding, the dentate gyrus (DG) plays a vital role in pattern separation and pattern integration of concepts because it is a brain region with substantial neurogenesis in adult mammals. Although concept coding properties of the brain have been extensively studied by experimental work, modeling of the process to guide both further experimental studies and applications such as natural language processing is scarce. To model brain-like concept coding, we built a spiking neural network inspired by adulthood neurogenesis in the DG. Our model suggests that neurogenesis may facilitate integration of closely related concepts and separation of less relevant concepts. Such pattern agrees with the previous experimental observations in classification tasks and place cells in the hippocampus. Therefore, our simulation provides insight for future experimental studies on the neural coding difference between perception and cognition. By presenting 14 contexts each containing 4 concepts to the network, we found that neural responses of the DG changed dynamically as the context repetition time increased and were eventually consistent with the category organization of humans. Thus, our work provides a new framework of word representation for the construction of brain-like knowledge map.

SUBMITTER: Wang Y

PROVIDER: S-EPMC6877936 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundAdult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activation and degradation of regulatory proteins. Among them, D-type cyclins control the exit from the G1 phase of the cell cycle. Cyclin D2 (cD2) has been shown to be required for the generation of new neurons in the neurogenic niches of the adult brain. It is differentially expressed during hippocampal development, and adult cD2 knock out (cD2KO) mice virtually lack neurogenesis in the dentate gyrus and olfactory bulb. In the present study we examined the dynamics of postnatal and adult neurogenesis in the dentate gyrus (DG) of cD2KO mice. Animals were injected with bromodeoxyuridine at seven time points during the first 10 months of life and brains were immunohistochemically analyzed for their potential to generate new neurons.ResultsCompared to their WT litters, cD2KO mice had considerably reduced numbers of newly born granule cells during the postnatal period, with neurogenesis becoming virtually absent around postnatal day 28. This was paralleled by a reduction in granule cell numbers, in the volume of the granule cell layer as well as in apoptotic cell death. CD2KO mice did not show any of the age-related changes in neurogenesis and granule cell numbers that were seen in WT litters.ConclusionsThe present study suggests that hippocampal neurogenesis becomes increasingly dependent on cD2 during early postnatal development. In cD2KO mice, hippocampal neurogenesis ceases at a time point at which the tertiary germinative matrix stops proliferating, indicating that cD2 becomes an essential requirement for ongoing neurogenesis with the transition from developmental to adult neurogenesis. Our data further support the notion that adult neurogenesis continuously adds new neurons to the hippocampal network, hence increasing cell density of the DG.

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Modeling of Brain-Like Concept Coding with Adulthood Neurogenesis in the Dentate Gyrus.

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