Ontology highlight
ABSTRACT:
SUBMITTER: Tremoulet AH
PROVIDER: S-EPMC6878161 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Tremoulet Adriana H AH Jain Sonia S Jone Pei-Ni PN Best Brookie M BM Duxbury Elizabeth H EH Franco Alessandra A Printz Beth B Dominguez Samuel R SR Heizer Heather H Anderson Marsha S MS Glodé Mary P MP He Feng F Padilla Robert L RL Shimizu Chisato C Bainto Emelia E Pancheri Joan J Cohen Harvey J HJ Whitin John C JC Burns Jane C JC
The Journal of pediatrics 20190924
<h4>Objectives</h4>To determine the safety, tolerability, pharmacokinetics, and immunomodulatory effects of a 6-week course of atorvastatin in patients with acute Kawasaki disease with coronary artery (CA) aneurysm (CAA).<h4>Study design</h4>This was a Phase I/IIa 2-center dose-escalation study of atorvastatin (0.125-0.75 mg/kg/day) in 34 patients with Kawasaki disease (aged 2-17 years) with echocardiographic evidence of CAA. We measured levels of the brain metabolite 24(S)-hydroxycholesterol (2 ...[more]