Dataset Information
Bombyx mori gloverin A2 alleviates enterotoxigenic Escherichia coli-induced inflammation and intestinal mucosa disruption.
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ABSTRACT: Background
Enterotoxigenic Escherichia coli (ETEC) is one of the leading bacterial causes of intestinal inflammation and diarrhea. However, the ETEC is frequently resistant to common antibiotics. In this study, we explored the role of a novel antibacterial peptide Bombyx mori gloverin A2 (BMGlvA2) in alleviating ETEC-induced inflammation and intestinal epithelium disruption in mice.Methods
An ETEC-challenged mice model was used, and the ETEC-challenged mice and non-challenged mice were treated by the BMGlvA2 at different doses.Results
ETEC challenge not only elevated the concentrations of serum inflammatory cytokines such as the IL-6 and TNF-? (P?P?P?P?P?ConclusionOur results suggested a novel function of the conventional antibacterial peptides, and the anti-bacterial and anti-inflammatory properties of BMGlvA2 may allow it a potential substitute for conventionally used antibiotics or drugs.
SUBMITTER: Lin Q
PROVIDER: S-EPMC6878672 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
<i>Bombyx mori</i> gloverin A2 alleviates enterotoxigenic <i>Escherichia coli</i>-induced inflammation and intestinal mucosa disruption.
Antimicrobial resistance and infection control 20191126
<h4>Background</h4>Enterotoxigenic <i>Escherichia coli</i> (ETEC) is one of the leading bacterial causes of intestinal inflammation and diarrhea. However, the ETEC is frequently resistant to common antibiotics. In this study, we explored the role of a novel antibacterial peptide <i>Bombyx mori</i> gloverin A2 (BMGlvA2) in alleviating ETEC-induced inflammation and intestinal epithelium disruption in mice.<h4>Methods</h4>An ETEC-challenged mice model was used, and the ETEC-challenged mice and non- ...[more]