Dataset Information

Comprehensive Genome Analysis of Carbapenem-Resistant Raoultella spp. strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

ABSTRACT: We report the characterization of six carbapenem-resistant Raoultella spp.(CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent the CRRS dissemination.

SUBMITTER: Yu X

PROVIDER: S-EPMC6879265 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Comprehensive Genome Analysis of Carbapenem-Resistant <i>Raoultella spp.</i> strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

Yu Xiao X Zheng Beiwen B Zhang Jing J Xu Hao H Xiao Tingting T Zhou Yanzi Y Zhang Shuntian S Zhu Yunying Y Wang Yuan Y Xiao Yonghong Y

Antimicrobial agents and chemotherapy 20190930 12

We report the characterization of six carbapenem-resistant <i>Raoultella spp.</i>(CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very val ...[more]

PMID: 31570399

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Project description:We aimed to identify the prevalence and emerging status of multidrug-resistant bacteria and fungi and their associated mortality in nine countries in the Arabian Peninsula. Original research articles and case studies regarding multidrug-resistant bacteria and fungi in the Arabian Peninsula, published during the last 10 years, were retrieved from PubMed and Scopus. A total of 382 studies were included as per the inclusion and exclusion criteria, as well as the PRISMA guidelines, from a thorough screening of 1705 articles, in order to analyse the emerging status and mortality. The emerging nature of >120 multidrug-resistant (MDR) bacteria and fungi in the Arabian Peninsula is a serious concern that requires continuous monitoring and immediate preventive measures. More than 50% (n = 453) of multidrug-resistant, microbe-associated mortality (n = 871) in the Arabian Peninsula was due to MDR Acinetobacter baumannii, Mycobacterium tuberculosis and Staphylococcus aureus infection. Overall, a 16.51% mortality was reported among MDR-infected patients in the Arabian Peninsula from the 382 articles of this registered systematic review. MDR A. baumannii (5600 isolates) prevailed in all the nine countries of the Arabian Peninsula and was one of the fastest emerging MDR bacteria with the highest mortality (n = 210). A total of 13,087 Mycobacterium tuberculosis isolates were reported in the region. Candida auris (580 strains) is the most prevalent among the MDR fungal pathogen in the Arabian Peninsula, having caused 54 mortalities. Active surveillance, constant monitoring, the development of a candidate vaccine, an early diagnosis of MDR infection, the elimination of multidrug resistance modulators and uninterrupted preventive measures with enhanced data sharing are mandatory to control MDR infection and associated diseases of the Arabian Peninsula. Accurate and rapid detection methods are needed to differentiate MDR strain from other strains of the species. This review summarises the logical relation, prevalence, emerging status and associated mortality of MDR microbes in the Arabian Peninsula.

Dataset Information

Comprehensive Genome Analysis of Carbapenem-Resistant Raoultella spp. strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

Publications

Comprehensive Genome Analysis of Carbapenem-Resistant <i>Raoultella spp.</i> strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

Similar Datasets

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