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Comprehensive Genome Analysis of Carbapenem-Resistant Raoultella spp. strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.


ABSTRACT: We report the characterization of six carbapenem-resistant Raoultella spp.(CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very valuable to prevent the CRRS dissemination.

SUBMITTER: Yu X 

PROVIDER: S-EPMC6879265 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Comprehensive Genome Analysis of Carbapenem-Resistant <i>Raoultella spp.</i> strains, an Emerging Multidrug-Resistant Bacteria in Hospitals.

Yu Xiao X   Zheng Beiwen B   Zhang Jing J   Xu Hao H   Xiao Tingting T   Zhou Yanzi Y   Zhang Shuntian S   Zhu Yunying Y   Wang Yuan Y   Xiao Yonghong Y  

Antimicrobial agents and chemotherapy 20190930 12


We report the characterization of six carbapenem-resistant <i>Raoultella spp.</i>(CRRS) in our hospital and a genomic analysis of 58 publicly available isolates. CRRS isolates are sporadically identified around the world and different transposons carrying carbapenemases were the resistant mechanisms. Mobile genetic elements play an important role in acquiring antibiotic resistant genes from the hospital. An improved understanding of these transposon and targeted control measures will be very val  ...[more]

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