Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity.

ABSTRACT: Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited understanding of therapeutic mechanisms and the lack of a robust feedback signal for tailoring stimulation. We recently reported that subthalamic nucleus deep brain stimulation evokes a neural response resembling a decaying high-frequency (200-500?Hz) oscillation that typically has a duration of at least 10?ms and is localizable to the dorsal sub-region. As the morphology of this response suggests a propensity for the underlying neural circuitry to oscillate at a particular frequency, we have named it evoked resonant neural activity. Here, we determine whether this evoked activity is modulated by therapeutic stimulation - a critical attribute of a feedback signal. Furthermore, we investigated whether any related changes occurred in spontaneous local field potentials. Evoked and spontaneous neural activity was intraoperatively recorded from 19 subthalamic nuclei in patients with Parkinson's disease. Recordings were obtained before therapeutic stimulation and during 130?Hz stimulation at increasing amplitudes (0.67-3.38?mA), 'washout' of therapeutic effects, and non-therapeutic 20?Hz stimulation. Therapeutic efficacy was assessed using clinical bradykinesia and rigidity scores. The frequency and amplitude of evoked resonant neural activity varied with the level of 130?Hz stimulation (p?

SUBMITTER: Sinclair NC 

PROVIDER: S-EPMC6879321 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature